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Stress can have a profound impact on the "gut-brain axis," often overriding the benefits of any diet or supplement

for the treatment of heart disease in people with obesity (FDA)

ADA 2026 emphasizes individualized care in older adults, with attention to nutrition, functional status, and overtreatment avoidance Thyroid caution Avoid in: Medullary thyroid carcinoma (MTC) MEN-2 syndrome This remains a boxed warning / contraindication in current labels